Association between a 15q25 gene variant, smoking quantity and tobacco-related cancers among 17 000 individuals
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چکیده
منابع مشابه
Association between a 15q25 gene variant, smoking quantity and tobacco-related cancers among 17 000 individuals.
BACKGROUND Genetic variants in 15q25 have been identified as potential risk markers for lung cancer (LC), but controversy exists as to whether this is a direct association, or whether the 15q variant is simply a proxy for increased exposure to tobacco carcinogens. METHODS We performed a detailed analysis of one 15q single nucleotide polymorphism (SNP) (rs16969968) with smoking behaviour and c...
متن کاملA sex-specific association between a 15q25 variant and upper aerodigestive tract cancers.
BACKGROUND Sequence variants located at 15q25 have been associated with lung cancer and propensity to smoke. We recently reported an association between rs16969968 and risk of upper aerodigestive tract (UADT) cancers (oral cavity, oropharynx, hypopharynx, larynx, and esophagus) in women (OR = 1.24, P = 0.003) with little effect in men (OR = 1.04, P = 0.35). METHODS In a coordinated genotyping...
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This review summarizes the carcinogenic effects of tobacco smoke and the basis for interaction between tobacco smoke and genetic factors. Examples of published papers on gene-tobacco interaction and cancer risk are presented. The assessment of gene-environment interaction in tobacco-related cancers has been more complex than originally expected for several reasons, including the multiplicity of...
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BACKGROUND Two single-nucleotide polymorphisms, rs1051730 and rs16969968, located within the nicotinic acetylcholine receptor gene cluster on chromosome 15q25 locus, are associated with heaviness of smoking, risk for lung cancer, and other smoking-related health outcomes. Previous studies have typically relied on self-reported smoking behavior, which may not fully capture interindividual variat...
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ژورنال
عنوان ژورنال: International Journal of Epidemiology
سال: 2009
ISSN: 1464-3685,0300-5771
DOI: 10.1093/ije/dyp288